Hylenex Information & Instructions

What is Hylenex?

Hylenex (generic name: hyaluronidase) is an enzyme that breaks down hyaluronic acid (HA), the primary ingredient in most dermal fillers (e.g., Juvederm, Restylane, Versa). It is used to:

• Correct overfilled or uneven areas
• Reverse unwanted filler results
• Treat complications such as lumps, nodules, or vascular occlusion
• Prepare an area for new filler placement

 

Hylenex starts working within minutes, and visible improvement typically occurs within 24–72 hours, though full breakdown can take up to 7 days or more depending on the amount and location of filler.

Important Notes

• Hylenex only dissolves hyaluronic acid-based fillers. It does not affect other filler types (e.g., Radiesse, Sculptra).
• In some cases, multiple sessions may be needed to fully dissolve the filler.
• Because your body naturally contains some HA, there is a chance Hylenex may affect your own natural HA as well, although it regenerates over time.
• If you’re planning to re-fill the area, this is typically done 7–14 days after Hylenex to allow full enzyme clearance and tissue settling.

 

Pre-Treatment Instructions

To minimize bruising and improve safety:

• Avoid blood thinners for 3–5 days prior:
• Aspirin, ibuprofen, naproxen, fish oil, vitamin E, garlic
• Avoid alcohol for 24 hours before treatment.
• Optional: Begin Arnica supplements 1–2 days prior to help reduce bruising.
• Let your provider know if you have any:
• Allergies to bee stings or animal proteins
• Previous reaction to hyaluronidase
• History of anaphylaxis

 

Post-Treatment Instructions

What to Expect:

• Mild swelling, redness, tenderness, or bruising at the injection site.
• Dissolution can start within hours, with continued improvement over several days.
• Treated areas may feel softer or slightly sunken temporarily — this is normal as filler dissolves.
• If significant filler was removed, you may notice volume loss or asymmetry.

 

Aftercare Tips:

• Apply a cold compress (10–15 minutes at a time) for the first 24 hours to reduce swelling.
• Use Tylenol (acetaminophen) if needed. Avoid NSAIDs for 24 hours.
• Sleep with your head elevated the first night.
• Avoid touching, pressing, or massaging the area unless directed by your provider.
• Hydrate well — staying hydrated supports tissue recovery.

 

Avoid for 24–48 Hours:

• Strenuous exercise
• Alcohol and smoking
• Makeup on the treated area
• Heat exposure (saunas, steam rooms, hot yoga)
• Other cosmetic procedures in the same area (e.g., microneedling, lasers)

 

If Planning Re-Filler

If you plan to have the area re-treated with new filler:

• Wait at least 7–14 days post-Hylenex to allow:
• Complete enzyme clearance
• Swelling to subside
• Accurate assessment of tissue structure

 

When to Contact Us

Call the office immediately if you experience:

• Persistent or worsening swelling or pain
• Severe bruising or discoloration
• Signs of infection (fever, warmth, pus)
• Allergic reaction (itching, rash, difficulty breathing)
• Any new or concerning symptoms